Ratz lab


Questions and approaches

We are interested in understanding the principles that govern the formation and function of the mammalian brain across scales ranging from genes to neural circuits:
  • What is the molecular and cellular architecture of neural circuits in the mammalian brain?
  • How do single neurons choose specific synaptic partners from many potential targets during brain development?
  • How do mutations in risk genes lead to neurodevelopmental disorders (e.g. autism spectrum disorder)?
To tackle those questions, we employ and develop cutting edge technologies with a special focus on the following areas:
  • Cellular barcodes for lineage and/or synaptic connectivity tracking in vivo
  • Spatial transcriptomics to decode gene expression with 3D resolution in situ
  • Bioinformatic methods for exploratory data analysis of large genomic datasets
  • Genome engineering in cells and animals for scalable studies of gene function

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